China Wuxi Jangli Machinery Co., Ltd. Company News

The soft capsule filling machine has complete functions, buzzer alarm when the hopper is empty, automatic shutdown when empty capsules are not enough, and the filling function of pellets, granules and tablets can be installed according to user requirements, which can meet 3 kinds of materials, and can meet the requirements of slow-release, controlled-release and tablet. The need for medicines to be contained in the same capsule. The bottom of the metering disc of the filling machine is embedded with a sealing device, which improves the powder leakage condition, reduces the wear of the parts, and is more convenient for cleaning. , while reducing the dust on the work surface.   The soft capsule filling machine integrates ingredients through pretreatment, adds pure water, solid granular medical bone glue, additives, vitamins, glycerin, etc. in a certain proportion, and stirs the glue at a low temperature of 70-80 °C, and vacuumizes the glue after a period of time. After the air bubbles and a certain amount of water in the glue solution are removed, the glue solution is placed in a gelatin bucket and allowed to stand, and the glue solution that has been left for a period of time is heated by the filling machine to the left and right of the gelatin box. The solid rubber is then passed through the left and right molds on the machine head, and the medicine is injected into the rubber by the spray body, and the finished pills are sent to the drying system through the conveyor for low-temperature drying.   But it has shortcomings, mainly reflected in its drying system:   From the perspective of the structure of the equipment, the drying system of the soft capsule filling machine is designed according to the manual rotary ordinary drying equipment. The method used is manual drying. In general, this method is difficult to achieve the initial setting of the soft capsule. Require. Because the speed of the dryer is difficult to adjust during operation, and it cannot be turned over regularly, it often comes out.

  The desktop soft capsule machine is mainly used to pack round and round granular items in pharmaceutical, chemical and industrial products. Such as: sugar-coated tablets, plain tablets, steel balls, capsules and other materials packaging. It can continuously and automatically complete the whole process of bag making, measuring, filling, sealing, slitting, counting and other packaging. It is also equipped with a photoelectric trademark positioning device, and can also add functions such as typing and incision.   The medicines made by the soft capsule machine process are:   1. Oily drugs and low melting point drugs are most suitable for making soft capsules. Oily drugs and drugs that are liquid or semi-solid at room temperature, in the past, for preparation, they were often processed by adsorption, curing and other technologies during preparation. Due to the addition of adsorbents and other auxiliary materials, the volume increased, or the preparation required heating and drying. At this time, the drug is easily freed or exuded from the adjuvant such as the adsorbent, which will cause the loss of the main drug and affect the curative effect. But soft capsules are made by dissolving oily drugs and low-melting drugs with a soluble solvent or making them into an emulsion for filling or dropping pills, eliminating the need for adsorption auxiliary materials, not only miniaturizing the preparation, but also avoiding the release and exudation of the drug. Wait for the problem to appear. Such as Vitex oil capsules and indomethacin farnesoid capsules.   2. Drugs that are sensitive to light, unstable in the presence of humidity and heat, and easily oxidized can be made into soft capsules. Some drugs, such as volatile oils, are sensitive to light; some drugs are easily decomposed and volatilized when exposed to heat and humidity; some drugs are easily oxidized during preparation and storage. In order to prevent the drug from being decomposed by light, a light-shielding material such as titanium dioxide or iron oxide can be added to the capsule material for preparing the capsule, which will achieve good light stability. In order to prevent the medicine from contacting with air, inert gas can be introduced during the preparation process. The capsule material of soft capsule is composed of glycerin and gelatin, etc., with thick wall and no air permeability, so soft capsule is an excellent preparation for preventing drug oxidation. Such as E capsules, active D3 capsules and Luo calcium capsules.   3. Soft capsules can be made into rectal suppositories. The method is as follows: dissolving the main drug or making it into an oil-soluble suspension to prepare a soft capsule, and then using the capsule to make a suppository. Compared with the general suppository, the rectal capsule suppository is easier to diffuse and absorb in the rectum, and the preparation method is simpler than the general suppository, and the use is convenient. There are rectal capsules such as betamethasone and indomethacin that have been listed abroad.   4. It is a unique feature that drugs with bad smell and soft capsules of trace active drugs can cover up the bad smell of drugs. Some trace active drugs are in very small doses and are best made into soft capsules.   5. The drug soft capsule with volatile components and easy to escape can not only ensure the loss of volatile components in the medicinal materials, but also avoid the loss of volatile oil after the preparation is placed, and improve the quality and efficacy of the drug.   6. Hydrophobic drugs with poor bioavailability can be made into microemulsions with oily carriers and then put into soft capsules, which can greatly improve their bioavailability. If other solid preparations are used, it is difficult for these drugs to achieve effective blood concentration.

The soft capsule production line is designed for laboratory pharmaceutical research and development, cosmetics, health care products, and military supplies. The model and output match the specifications. Considering the elastic characteristics of output, the equipment can be upgraded and transformed to speed up the output without the need to purchase new equipment. Therefore, the equipment has a wide range of compatibility, and one set of equipment can adapt to multiple production levels, so from the perspective of safety, the economic advantages of our company's products are considerable.   Common faults and troubleshooting methods of soft capsule production line in the production process:   1. The rubber skin is split or grooves appear. ——Cause: There may be dry glue or mechanical debris on the baffle at the glue outlet of the gelatin box. );   2. The rubber skin is uneven or shows wavy lines with hard glue---reason: the rubber skin is oily-the bottom of the rubber skin can be wiped clean with a cloth;   3. The rubber sticks to the rubber wheel——the amount of cold air is too small, the air temperature or the temperature of Mingjiao is too high——the amount of cold air can be increased, and the temperature of Mingjiao can be reduced;   4. The width of the rubber is not enough - there are obstacles at the outlet of the gelatin box, and the amount of cold air is too large - clear the obstacles and reduce the amount of cold air;   5. Capsule seam cracking——the rubber skin is too thick, the gelatin random cloth is qualified, the rolling die is wrong, the temperature of the spray body is too low, and the material liquid cloth is adapted——the thickness of the rubber skin can be reduced, the gelatin can be replaced, and the line can be re-aligned , Increase the temperature of the spray body, check the material liquid;   Capsule filling quantity distribution --- air in the material liquid, material liquid is too thick to stick or precipitate at the end of the piston rod, seal leakage of the feed pump plunger feed pipe or mechanical debris in the spray body--- can be excluded Air in the liquid, increase the stroke of the feeding pump for a few minutes, re-batch, replace the seal, etc.;   In addition, the disintegration delay problem of soft capsules may not only be affected by a, capsule shell (material, composition ratio, thickness, water content) b contents c external environment (storage conditions), but also related to production process conditions such as soft capsules Too long drying time, too high drying temperature and too high humidity will accelerate its aging and affect disintegration.  

With new technology on the softgel encapsulation machine, we are glad to attend to SHANGHAI CPHI exhibition this year. It is good time to have talk face to face with old friend and also new friend. You are welcome to come here and meet us again next year  

Formulation Of Soft Gelatin Capsules，What Are Gelatin Capsules Made Of     The formula of soft gelatin capsules is different for each company. Normally, the main ingredients are glycerin, gelatin, water, and some factories will add some special excipients, titanium dioxide, iron oxide, PEG400, sorbitol, etc. The gelatin capsule is composed of gelatin, and medicinal gelatin is a high-grade gelatin product with no fat and high protein that is easily absorbed by the human body, and is prepared from animal skin, bone and tendon through complex physical and chemical treatment. The main materials of hard hollow capsules are gelatin: the main materials of soft hollow capsules are gelatin and glycerin; the main materials of enteric hollow capsules are gelatin or sodium alginate, and then coated with enteric materials such as pvp as a subcoat and then capped for outsourcing. Clothes.   Vegetable capsules are hollow capsules made of plant cellulose or water-soluble polysaccharides to meet the needs of all-natural positioning and capsule formulation solutions. It retains all the advantages of standard hollow capsules: easy to take, effective masking of taste and odor, transparent and visible contents, etc., and at the same time, it has the connotation that traditional gelatin capsules do not have.   What we usually see now is gelatin capsules, which are composed of gelatin. Medicinal gelatin is a high-grade gelatin that is easily absorbed by the human body without fat and high in protein, and is prepared from animal skin, bone and tendon through complex physical and chemical treatment. It has the physical characteristics of high viscosity, high freezing force and easy freezing. Capsules are usually divided into hard capsules and soft capsules. 1. Hard capsules are made by preparing a certain amount of drugs (or medicinal material extracts) and appropriate auxiliary materials (or without auxiliary materials) into uniform powder or granules, and filling them into hollow hard capsules. 2. Soft capsules are made by dissolving a certain amount of drugs (or medicinal material extracts) in appropriate auxiliary materials, and then sealing them in spherical or olive-shaped soft capsules by compression method (or drop method). Of course, it can also be further divided into the third category according to the particularity of the use: enteric-coated capsules Enteric-coated capsules are actually a kind of hard capsules or soft capsules, but a special capsule is added to the shell. The medicinal polymer material or special treatment, so it does not dissolve in gastric juice, and only disintegrates and dissolves in intestinal juice to release active ingredients, achieving an enteric effect, so it is called enteric-coated capsules.

A Closer Look at Wuxi Jangli Machinery Co. Ltd With more than two decades of experience under their belt, the Wuxi Jangli Machinery Company is an ideal source of softgel encapsulation machines. Located in China, they are a mass producer with a 6,000m2 workshop. They have more than 300 technicians, engineers and other workers or members of staff. Along with this, they have more than 20 sets of CNC processing centers. They develop die rollers and precision tools in these stations. Wuxi Jangli Machinery Co. Ltd is a Large Scale Capacity producer. They sell more than 100 softgel encapsulation machine sets annually. In addition to that, they also sell more than 1,000 softgel die roller sets covering all types of brands, or models. To ensure product variety, the company also sells more than 300 tumble dryer baskets for smart or common tumble dryers. Furthermore, they also sell more than 50 lines of softgel machine accessories. As such, the Wuxi Jangli Machinery Company is a one-stop shop for all equipment related to softgel encapsulation machines. By ranking as one of the top softgel encapsulation machine manufacturers, the company attracts clients to inspect their facilities and set up cooperative deals.   Wuxi Jangli Machinery Company Softgel Encapsulation Machines There is a wide variety of softgel encapsulation machines available from Wuxi Jangli Machinery Co. Ltd. One of these is the JL-300II. It is the largest softgel encapsulation machine for Large Scale Capacity production. It is the company's flagship model. In addition to large volumes of production, it can manufacture different types of softgel capsules. Here is more about it: The JL-300II This soft gelatin encapsulation machine was designed and built on two decades of industry experience. As a result, it exhibits the following advanced technology: Innovative Gelatin Ribbon Maker This is one of the main parts of the soft gelatin machine. It is made up of smaller, compact components. They include: The Spreader Box: This contains an automatic ribbon thickness monitor. This component accurately controls the thickness and saves energy costs by boosting efficiency. The Cooling Drum: Essential to the softgel manufacturing process, the cooling drum can be developed in a bespoke way according to client requirements. Its temperature can be adjusted from 15℃ to 65℃. Lubrication System: This system controls the amount of lubrication upon the inner and outer sides of the gelatin ribbon. Notably, this system has a 4-set Japanese flowmeter.   The Injection Pump The filling pressure applied upon your softgel capsules plays an important part in the quality of your final product. An injection pump determines the pressure's accuracy and serves as the heart of your softgel encapsulation machine. This pump features a combination of numerous plungers that range in number from 6 to 34 depending on your preference. Material Box This component of the softgel filling machine sits right above the injection pump. It has a two-layer design characterized by a mixer and water-heating capabilities. Notably, the material box has a cylinder shape for easier cleaning. Die Roll The die roll contains a mold for the soft gelatin capsules, and is responsible for encapsulation. In addition to that, it is equipped with features such as automatic injection time and automatic die alignment. Control Panel The JL-300II has a control panel through which the operator can monitor, configure, and set the machine's parameters. The panel is touch sensitive, and fully colored to clearly illustrate the machine's components. In case of an error, it will ring an alarm and highlight the malfunctioning component. The control panel is built by SIEMENS and contains a PLC drive.   Judging by its characteristics, the JL-300II is a powerful softgel encapsulation machine which can easily handle Large Scale Capacity production. Moreover, it is versatile and can be installed in a variety of facilities such as startups and medium to large softgel production factories. Reasons To Buy From the Wuxi Jangli Machinery Company   Stable Operations Wuxi Jangli Machinery Co. Ltd has been in active operation for more than 20 years. They have developed a human resource synergy that results in high-quality products and punctual deliveries. Moreover, they have developed a 6,000m2 workshop over this time.   Professional Service Delivery The company has more than 40 technicians whose job is to design and build softgel machines along with their protocols. There is also an army of service providers who respond to clients rapidly and resolve issues conclusively.   Product Line Delivery In addition to softgel encapsulation machines, the company also provides support equipment, and installation services. They also facilitate training, and perform troubleshooting for you. Along with this, they can also service your softgel encapsulation machines.   After Sales Services After purchasing a softgel-making machine from the Wuxi Jangli Machinery Company, they will facilitate quick delivery. In addition to that, they also install the machine in your facility, and conduct regular maintenance.   Conclusion Are you looking to mass produce softgel capsules for the pharmaceutical or the nutraceutical industries? Look no further than the JL-300II machine. Built by the Wuxi Jangli Machinery Company, this softgel encapsulation machine contains a collection of innovative features. It has a unique gelatin ribbon maker, an injection pump, and a SIEMENS touch sensitive control panel with a PLC drive. After buying a unit at an affordable softgel encapsulation machine price, the company will deliver, install, and maintain it for you. As such, Wuxi Jangli Machinery Co. Ltd has got you covered!  

With new die roller technology and new encapsulation technology, we attend 2019 CPHI in Frankfurt.  You are welcome to come and visit out booth C3110

You are welcome to visit our Booth E F40; we are attending CPHI in Shanghai with our new softgel encapsulation machine and tumbler dryers