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Latest company new about Production process for soft capsules
2024/04/12

Production process for soft capsules

Production process for soft capsules: The production process of soft capsules is as follows: ingredients, gelatinization, pill pressing, drying, pill picking, inner packaging, quality inspection, outsourcing Batching refers to the raw materials and accessories in the batching tank mixed heating, prepared to meet the standard of pure oil or non-pure oil substances, forming the content can enter the next process. In addition, if propolis, fish oil taurine and other raw materials contain solid powder, but also need to mix with oily ingredients, grinding machine into paste, to avoid solid-liquid stratification. Gelatinization is the process of putting solid granular gelatin into the gelatinizer by means of vacuum suction, adding pure water to melt into a proper viscosity of the gelatinizer, and then used in the production of pellets. In order to ensure quality, the production process must be on the viscosity of the glue filtration and regular testing Pill press refers to the production of the content and rubber delivery to the pill press production line, the production of pills. The process is as follows: at the left and right ends of the equipment, near the middle, there is a rubber plate. When they are about to meet, the small tube above will inject a certain amount of content, and then through the mold and spray the role of the content will be wrapped in rubber sheet peel. The process is similar to that of making dumplings. The balls are soft after pressing. The soft capsule needs to be dried in the drying room to form the pellets. The scientific two-stage drying technology of low temperature and high temperature is adopted, which greatly improves the drying efficiency. The dried pills will be transported to the pill concentrator. The pill with uneven shape is selected automatically by the pill selecting device. Then the qualified products for artificial light inspection, further remove the ball bubbles and other non-qualified products. Packing qualified products.
Latest company new about The preparation process of soft capsules and points for attention
2024/03/19

The preparation process of soft capsules and points for attention

Soft capsule is a kind of sealed capsule preparation, which is formed by encapsulating oily drug, drug solution or drug suspension with gelatin capsule shell. In this paper, the preparation process of soft capsule by pressing method and the matters needing attention were summarized. The basic principle of the pressing method is as follows: the rubber sheet passes through the middle of a pair of cylindrical moulds, the feeding pump injects a fixed amount of liquid medicine through the spray body between the rubber sheet, and the mould moves towards each other to press the two rubber sheets together and cut them out of the rubber sheet, form a completely closed capsule. The main technological steps of the pressing method include four steps: chemical glue, liquid preparation, pill making and drying. In addition, in order to ensure product quality, production will also increase the pill-testing process, eliminate unqualified products. (1) Gelatinization ① Feeding sequence Usually, a certain proportion of gelatin, plasticizer, and water are added to a gelatinizing tank for heating and stirring. The gelatin absorbs water and dissolves to form a gel solution. The above materials can be added simultaneously, but it is recommended not to directly add gelatin to hot water. Otherwise, due to the dissolution of gelatin that comes into contact with hot water first, a dense gelatin layer will be formed, and the gelatin particles wrapped inside are difficult to dissolve. There will be many clumps in the obtained gel solution, which will affect normal production. In addition, pigments or shading agents such as titanium dioxide and iron oxide may also be added to gelatin. Colloidal grinding should be used to grind it together with some plasticizers and water. After sieving, it can be added to the gel solution to avoid the preparation of rubber with spots or pores. ② Glue temperature It is generally advisable to control the temperature of the adhesive during production at 60-70 ℃. The main component of gelatin is a mixture of peptide molecules, and high temperatures can cause hydrolysis of peptide molecules, affecting the quality of the gelatin solution. ③ Vacuum degassing There will be many bubbles in the newly melted glue, so vacuum degassing operation is necessary. Vacuum degassing generally requires a vacuum degree of -0.07~-0.08 MPa. At the beginning, a large number of bubbles will roll and release from the adhesive solution. Therefore, it is important to release the pressure in a timely manner to avoid pumping the adhesive solution into the vacuum pump and damaging the equipment. During the vacuum pumping process, attention should be paid to observing the state of the glue liquid until there are no obvious bubbles released on the surface, and the glue liquid flows in a honeycomb shape on the surface, indicating that the degassing is completed. The vacuum pumping operation can be stopped. The vacuum pumping time should not be too long, otherwise the glue liquid will lose a large amount of water, which will affect the subsequent shot pressing operation. ④ Glue insulation The insulation temperature of the adhesive solution is generally controlled between 50-60 ℃. If the temperature of the adhesive solution is too low, it will lead to a decrease in the fluidity of the adhesive solution. Therefore, during the pelletizing stage, the adhesive solution still needs to be reheated, which takes a long time and may result in uneven properties of the adhesive solution. The glue should not be used immediately after vacuum degassing is completed. It should be left to stand for more than 4 hours to fully discharge the bubbles in the glue. The upper limit of insulation time is evaluated based on specific projects, and the viscosity, freezing force, and moisture of the adhesive during the insulation process can be monitored to determine the stability of the adhesive quality during the insulation process. (2) liquid preparation The contents can be prepared according to the requirements of specific projects, according to the relevant solution, suspension, semi-solid preparation of the relevant technical requirements, to control the dispensing process. If the raw materials have light, heat, oxygen instability, can consider the light, cooling or nitrogen. The process of liquid preparation varies from one project to another, so it is not discussed in detail here.   (3) making pills Pressing pills is the core work of the production of soft capsules. The prepared medicine liquid is added to the hopper, and the glue liquid is pressed and sent to the soft capsule machine through the conveying pipe, complete the preparation of rubber, content of quantitative filling, through the mold will be the rubber and content of the pressed into capsules. The main process parameters to be controlled are as follows: ① Rubber thickness If it is a generic formulation, it is recommended to maintain the same thickness of the soft capsule shell as the reference formulation to ensure consistent disintegration time. A certain prescription can be used to apply wet rubber with different thicknesses, and after drying, the thickness of the dry rubber can be measured to determine the target rubber thickness range. In general, the thickness of rubber with a weight of 1g or more is controlled within 0.8-0.9mm, and the thickness of rubber with a weight of less than 1g is 0.7-0.8mm. Excessive thickness of the rubber may result in a higher spray temperature required, otherwise it may not have a good stitching effect. Thin rubber can affect the compressive strength of soft capsules, which is not conducive to storage and transportation. In addition, the thickness of the two pieces of rubber should be as consistent as possible, otherwise it will produce deformed pellets. ② Spray temperature The spray temperature should be adjusted according to the condition of the rubber. If the moisture content of the rubber is too low or the rubber is too thick, the spray temperature should be appropriately increased. In addition, if the pressing speed of the shot is too high, it is also necessary to increase the spray temperature to ensure a better stitching effect. Usually, the temperature of the spray should be controlled between 35 ℃ and 40 ℃. If it is too low, it is difficult to sew, and if it is too high, it may cause the soft capsule suture line to twist and produce shaped pills. ③ Ball pressing speed The increase in shot pressing speed may not only affect the spray temperature, but also affect the thickness of the rubber coating. A faster rotation speed can cause excessive stretching of the rubber during the shot pressing process, resulting in thinning of the rubber. Therefore, after adjusting the shot pressing speed, the thickness of the rubber should be monitored to ensure that it is within the target range. ④ Environmental temperature The ambient temperature during the pressing process can also have an impact on the pressing effect. If the ambient temperature is too high, it may cause the pressed pellets to cool slowly and cause adhesion; If the ambient temperature is too low and the rubber is difficult to sew, it is necessary to increase the spray temperature appropriately. ⑤ Other The soft capsule machine also has the temperature of the rubber conveying tube, the temperature of the rubber box, and the temperature of the cooling drum. The temperature of the rubber conveying tube and the temperature of the rubber box are generally 55-60 ℃ to ensure that the glue can flow smoothly and not cause blockage of the rubber conveying tube; The cooling drum is generally controlled below 20 ℃ to ensure that the rubber can be quickly cooled and formed. In addition, attention should be paid to the type and amount of lubricating oil added during the pill making process, and corresponding quality standards should be established for the lubricating oil. There should be sufficient evidence to prove that the lubricating oil will not affect other components of the soft capsule. Commonly used lubricating oils include medicinal grade liquid paraffin and medium chain glycerides. (4) Drying The drying process is generally divided into two steps, namely fixed drying and static drying. The newly compressed soft capsules will be immediately transferred to a drying rotary cage for drying, reducing the moisture content to 25-30%. Under this moisture content, the shape of the soft capsules will be basically fixed. To improve production efficiency, transfer the shaped and dried soft capsules to a tray for further drying. To clean the lubricating oil on the surface of the soft capsule, an oil absorbing cloth can be added to the drying basket during the shaping and drying process. Generally, the moisture content of soft capsule shells should be controlled between 8-12%. If the moisture content is too high, the finished capsule shell will be too soft and prone to mold; If the moisture is too low, the capsule shell will crack, which is not conducive to storage and transportation. The main factors affecting the drying effect of soft capsules are as follows: ① Environmental temperature and humidity The study by Liu Hongyan et al. shows that changes in drying conditions have an impact on the drying rate of soft capsules, as shown in Figure 3. The temperature and sound of the drying environment are high, and the soft capsules dry quickly in the early stage of drying. However, in the later stage of drying, due to the surface drying and hardening of the capsule shell, it affects the internal water conduction and the drying rate decreases. As the environmental humidity decreases, the drying rate shows an accelerating trend. In general, the humidity in the environment should be controlled below 60%, otherwise it is extremely difficult for the capsules to dry. ② Dry wind speed Increasing the wind speed in a dry environment can increase the water transfer rate and improve drying efficiency. ③ Drying time Under strict control of environmental temperature and humidity, the moisture content of dried soft capsules depends on the length of drying time. During the process investigation stage, capsules with different drying times can be taken to measure the moisture content of the capsule shell, and a drying curve can be drawn to determine the drying endpoint. (3) testing pills The pill-checking process is to eliminate the unqualified products in the dry soft capsules, such as large and small pills, deflated pills, bubble pills, shaped pills and so on. The general way of taking pills is to put the soft capsules on the lamp table and pick them by hand. In the process of soft capsule preparation, we need to evaluate the output material attributes of each process to ensure the output of qualified products. In the chemical glue stage, the appearance, moisture, viscosity and freezing force of the glue are the general indexes. The appearance of the glue should be fine and smooth without fine bubbles, water should be controlled at 40% -50% , water is too low, in the process of pressing pills will be difficult to suture, too much water will lead to the formation of rubber; If the viscosity is too low, the soft capsule shell is easy to be saponified. The two indexes should be monitored in the course of heat preservation to prevent the quality of gelatin from decreasing too much. In the pill-making stage, the appearance of the soft capsule, the amount of the soft capsule and the stitching condition, the appearance of the soft capsule, whether there are bubbles on the surface of the capsule, whether the stitching is even, the amount of the soft capsule must be cut open, after erasing the contents, the weight of the capsule was determined, and ether was recommended to clean the contents in the quality standard of preparation. The content is the difference between the total weight of the capsule and the weight of the capsule skin. The content should be determined immediately after the sample is taken out. If the waiting time is long, the accuracy of the content determination will be affected after the moisture of the soft capsule evaporates, the soft capsules shall be kept in an airtight container and placed at a low temperature to prevent the evaporation of water, and the stitching shall be observed under a microscope, determined by cutting the newly made soft capsules and cutting off the middle ring of rubber, under the microscope to observe the thickness of the rubber and the thickness of the seam, the microscope image as shown in figure 5, measuring and calculating the seam rate, the general suture rate should not be less than 30% . Suture rate = seam thickness/capsule thickness * 100% During the drying stage, the water content of the capsule should be monitored. The method of determination is to cut the soft capsule, wipe the contents of the capsule with oil-absorbent paper, and measure the water content of the capsule by the method of drying, until the moisture reaches the target range. If there is a proven method for monitoring moisture stability, it may also be used.    
Latest company new about Detail structure of softgel encapsulation machine
2024/01/15

Detail structure of softgel encapsulation machine

Structure of Softgel Encapsulation Machine   A soft capsule is made by oil base material. Is a major pharmaceutical dosage form. Now softgel capsules is not only for medicine, but also for soft capsule cosmetics, soft capsule animal drugs, soft capsule suppository, soft capsule candy, soft capsule bath beads. Those new products are popular with consumers.       The industrial production of soft capsules requires the use of a roll-die soft capsule equipment. It is softgel encapsulation machine. The main principle is to use two pieces of gelatin ribbon and inject material inside of pocket. After several hours drying, you can get final capsules.       Then we will talk about basic structure of softgel encapsulation machine. Soft encapsulation machine can be divided into three parts according to the basic principle. The first part is the gelatin ribbon making part, the second part is the material injection part, and the third part is the soft encapsulation part. Let's go through them all   The first part: The gelatin ribbon making part.   This part is used to change the gelatin liquid into gelatin ribbon skin. Therefore, the main components of this part are gelatin spreader box and gelatin cooling drum.       Let us start from gelain spreader box. The main function of the gelatin box is to expand the gelatin liquid to form a gelatin line. To achieve this function, the gelatin box is designed with a hand wheel which can adjust the thickness of gelatin. High degree of automation was designed with automatic gelatin ribbon adjust system which no need to adjust ribbon by PLC program.       In order to keep the gelatin liquid flowing well in the gelatin box, the gelatin box needs to have the function of heating. Therefore, the material of gelatin spreader box is brass which has good thermal conductivity, and not easy to deformation.   At present, the design of gelatin spreader boxes are used to store a certain amount of space for gelatin solution. Therefore, the supplement design of gelatin liquid includes automatic control supplement gelatin liquid and manual control supplement gelatin liquid.   At present most sofgel machine in market is applied with gelatin liquid automatic feeding design. The automatic filling of liquid gelatin is designed with pneumatic control. The gelatin spreader box has the liquid level sensor at top. when the sensor detects the liquid level has reached a certain height, the sensor signal will control the pneumatic valve to control the gelatin box into the valve to close.   The function of the cooling drum is to quickly cool the gelatin out of the spreader box into solid gelatin. Therefore, the cooling effect is an important parameter to consider the cooling drum. Antifreeze is stored inside the cooling drum. External Cooling through the water cooler to control the temperature of the wheel hub. The cooling coil is designed in the cooling drum, and the cooling water is exchanged with the antifreeze liquid in the cooling drum to reduce the temperature. For more accurate hub temperature control. When the temperature is close to the control point, the speed of the water pump will be slow, which will be more convenient for precise control of the temperature. The material of cooing drum is special steel material, suitable for working in cold water environment for a long time, and will not be distorted by working for a long time.   The second part: The Material Injection Part.   The material injection part of soft capsule machine is mainly composed of Hopper and material injection pump.       The Hopper is the part where the material is stored and is located at the top of the equipment. The Hopper can realize the function of automatically replenishing materials. When the hopper is full of material, the float sensor will inform software program to control the pressure valve, which opens and presses the material from the Compressed air into the hopper.       In order to make the material more even, there is a stirring paddle inside the hopper, the stirring paddle will keep stirring, this function is particularly useful for mixed materials. In addition, the hopper will be designed with heating function, heating design has heat conduction plate heating and jacket hot water heating, heating plate heating efficiency is fast, may not be uniform; jacket hot water heating efficiency is slow, but heating evenly. Because the material is not very sensitive to temperature, at present all the equipment are using heating plate heating or heating rod heating. The Hopper also has a sealed design, because the air oxidizes some medicines or materials, so some of these materials must be made in nitrogen soft capsule. Therefore, the hopper must have a good seal.       In addition is the hopper material, because the hopper must be in contact with the material, so the hopper material is food-grade contact material.     The injection pump is a very core part of the device, and it is the heart of the soft capsule machine. The material is transported to the mold section by this injection pump. The injection pump determines the accuracy and accuracy of soft capsules. Injection pump will decide the quality of softgel machine good or bad. The working principle of the injection pump is to push and pull the piston and switch the guide plate to achieve around the injection. Materials will be directly in contact with the injection pump, guide plate in the work will always switch back and forth. Therefore, a good injection pump not only have good wear-resistant materials, but also have good accuracy   At present our pump core material is 9Cr12Mo, this material has a good hardness, and wear resistance. At the same time, the accuracy and accuracy of the injection material can be guaranteed.       The third part: The encapsulation Part.   The soft capsule is in the form of two pieces of gelatin ribbon wrapped around a liquid material. Through the last two chapters we know the preparation of gelatin ribbon and the material delivery system. So in this chapter we will focus on how the capsule is used to wrap the liquid material.       The principle of soft capsule making is to use two die rollers to extrude gelatin ribbon, and at the same time, use a segment to inject material into the cavity of the die roller. The material injection process will stretch the capsule gelatin to the desired shape of the soft capsule. The die roller then continues to squeeze the top capsule to seal a complete capsule. The capsule will form. The whole process is dynamic. The die roller are rotated, the materials and gelatin are supplied, and a large number of soft capsules can be made. The main core components in this area are the injection wedge, the die, and the mangle roller.         Injection wedge: injection wedge is also called segment. The injection wedge can disperse material onto the die. Therefore, the injection wedge is matched with this die roller. In order to achieve better material injection synchronization, the injection wedge may need to be specially designed. As shown in the image below     Besides the function of dispersing material, another important function of the injection wedge is heating. The gelatin ribbon should have good elasticity and plasticity between 38 ~ 45 °C at suitable temperature. In this way, the die roller form a good joint when extruding. The temperature control of injection wedge is very important for the quality of soft capsule. Therefore, there are several forms of temperature control of injection wedge   1. The heating rod is heated directly, the heating rod is heated quickly and the adjusting temperature is quick, but the heating rod may be heated unevenly because of the manufacturing quality problem. Large temperature difference between the front and back of the phenomenon.     2. Water Heating: Inection wedge designed into the pipeline form. The hot water circulates in the Injection wedge directly to the left and right of the wedge. The injection wedge in this way is complicated in design and time-consuming in processing. But the temperature of it is better and uniform. Therefore, for products with strict quality requirements, it is necessary to use water heating spray.     3. Heat conducting oil mode: the Heat conducting oil wedge is a combination of the advantages of heating rod and water heating mode. The injection wedge is directly heated by heating rod, and many heat conducting oil pipelines are designed in the injection wedge. This provides more uniform heating in the form of a heat conducting oil. At the same time, heating efficiency will not be affected.     The die roller is the core component of the soft capsule. We can see the market is soft capsules in different shapes, round, olive, oblong, animal, fruit shapes... ... and this is done primarily through die roller. The die roller can make various shapes of cavity through the machining center. The die roller is made of food grade aviation aluminum. This material has good plasticity and wear resistance.   Die design is the main means to ensure the quality of soft capsule products. Die roller step, cavity size, cutting height, step height and so on very small craft will affect the soft capsule cutting effect, soft capsule seam effect... . At present, our die roller after 20 years of experience and customer feedback, die roller design has excellent results and brief introduction. For example, our die roller steps, a single step, two steps, three steps design. We will be based on the customer’s soft capsule products to recommend the appropriate design. Because of the many technical points of the mold, we will write a separate article to introduce.                    
Latest company new about Boost Your Softgel Business With A Softgel Encapsulation Machine From The Wuxi
2023/02/20

Boost Your Softgel Business With A Softgel Encapsulation Machine From The Wuxi

All About Wuxi Jangli Machinery Co. Ltd. For more than twenty years, Wuxi Jangli Machinery Co. Ltd. has manufactured and supplied softgel encapsulation machines. They also deliver the required supporting equipment. The company has a wide scale of operations distributed throughout a 6,000m2 workshop. They employ more than three hundred members of staff including engineers, technicians and support officers. In addition to that, the Wuxi Jangli Machinery Company has more than twenty sets of CNC processing centers developed for die rollers along with other precision tools. By utilizing their ample resources, the company is able to sell more than one hundred sets of softgel machines all over the globe annually. They also sell more than one thousand softgel die roller sets for all types of models or brands globally. The company also produces more than three hundred tumble dryer baskets for intelligent and regular machines annually. Along with this, the company also manufactures more than fifty lines of softgel machine complementary equipment for example gelatin melters, medicine tanks, and gelatin service tanks among others. Their high output makes them one of the biggest softgel encapsulation machine manufacturers. Their high-quality products inspire more and more clients to inspect and cooperate with Wuxi Jangli Machinery Co. Ltd.     Softgel Encapsulation Machines Available For You Wuxi Jangli Machinery Co. Ltd has a state-of-the-art Product Center where you can find a variety of machines. Each unit exhibits advanced technology and high-quality construction. Their softgel encapsulation machines meet all required industry standards thus assuring operational effectiveness. Softgel Encapsulation Machine Models The JL-50 The JL-50 soft gelatin capsule machine is ideal for product development. It proves essential in softgel craft study. With the JL-50, you can explore new product-trail manufacturing in health-care products, food, traditional Chinese medicine or the chemical industry. This machine is also perfect for teaching the process of soft gelatin encapsulation in tertiary institutions such as college or university. Notably, this softgel encapsulation machine price is pocket-friendly. The Wuxi Jangli Company created the JL-50 as a Small Scale Capacity softgel encapsulation machine. It has the following features: An Air Conditioner: The JL-50 is complemented by an air conditioner unit that eliminates all the exhaust fumes, and purifies the workshop's air at the same time. Compact Dimensions: The machine is designed to occupy a small surface area in your workshop. As a result, there's ample room around it for movement or securing complementary equipment. Die Roller: Made of stainless steel, its die roller has a diameter of 64mm x 65mm. This produces softgel capsules of a standard size that's applicable throughout the industry. Gelatin Spreader Box: Despite being a Small Scale Capacity machine, the JL-50 has a spacious gelatin spreader box. PLC WEINVIEW Touch Screen Panel: Users can configure and control the machine using a WEINVIEW touch sensitive control screen. Featuring full color display, it has a rapid response and is complemented by large Start, Stop and Set buttons. What are the Main Parts of a Softgel Encapsulation Machine? A soft gelatin machine depends on numerous parts to manufacture softgel capsules. Its main section is the PLC Control Panel. This touch sensitive panel provides a color, user-friendly User Interface (UI) through which you can monitor, program and configure the machine. The Medicine Pump directs material through a tube into the softgel encapsulation station. Also known as a material feeding pump, it is made of stainless steel. An Injection Wedge heats up the gelatin to an ideal temperature so as to make encapsulation possible. The wedge controls the temperatures using a combination of sensors. The Medicine Tank holds your liquid or semi-liquid fluid that is to be encapsulated. Made of stainless steel, it has a unique design which enables the smooth flow of medicine through the material pump system. Majority of medicine tanks have conical shapes that enable free flow of medicine. A Gelatin Spread Box extends molten gelatin to create thin strips that are ideal for the encapsulation procedure. Normally, the spread box covers the right and left sides of the softgel filling machine. Your machine's Cooling Drum releases excess heat from the gelatin ribbons. It can use water or air to cool your Gelatin Spread Box. For maximum effectiveness, there are two cooling drums on each side of the box. For maximum heat reduction, your softgel-making machine also has a chilling system. It removes excess heat from the gelatin shells to maintain a steady temperature. The Gelatin Melting and Mixing Tank contains all the ingredients that are required to manufacture the capsules. It is made of stainless steel resulting in rust-proof operation. Lubrication rollers apply lubricant on the gelatin ribbons for smooth encapsulation. They also tighten the gelatin film to get rid of wrinkles that could compromise quality. Composed of two main dyes, the Tooling System uses pressure to determine the shape and size of your softgel capsules. Stripper rollers remove any softgel capsules that could get stuck in the machine's mechanism. Always in motion, the Die Roll Brush plays a part in removing any softgel capsules that are stuck in the system. Finally, you can access your completed softgel capsules from the Discharge Chute. Why Buy Your Softgel Encapsulation machine from the Wuxi Jangli Company? Superior Quality Control Design Lead Quality: There are more than twenty designers who create professional designs and protocol for each client's machine. Raw Material Control: At Wuxi Jangli Machinery Co. Ltd, there are numerous tools to confirm the quality of raw materials used in manufacturing the machines. Each batch of raw materials is released with an official certificate. Efficient Production Management: The workshop applies advanced CNC procedures, and employs highly skilled workers to manufacture the machines. Product Testing: Each machine undergoes FAT testing to ensure operational effectiveness. To this effect, the injection accuracy is analyzed using a software system. Melter Testing: The gelatin melter undergoes vacuum, pressure and heating surface roughness testing.       Conclusion Are you looking to buy a soft gelatin encapsulation machine? Purchase it from Wuxi Jangli Machinery Co. Ltd. They have a wide variety of machines for example the JL-50, JL-100II, and the JL-150III. The JL-50 is a Small Scale Capacity machine fit for use in educational institutions, or in a startup company. It is easy to launch thanks to complementary equipment such as an Air Conditioner, and core tools such as the Gelatin Spreader Box. Rest assured that any machine from Wuxi Jangli Machinery Company will get the job done because it exhibits superior quality. Interested in a softgel encapsulation machine for sale? Buy a JL-50 softgel encapsulation machine today!
Latest company new about Basic production flow for Softgel Capsules Making Machine
2023/02/01

Basic production flow for Softgel Capsules Making Machine

Soft capsule refers to the dosage form made by sealing a certain amount of medicine or medicinal material extract with suitable auxiliary materials in a spherical or elliptical soft capsule material, which can be prepared by dropping method or compression method. Compared with other dosage forms, it has the advantages of high bioavailability, accurate content, good uniformity, masking the bad smell of the drug itself, improving the stability of the drug, and beautiful appearance. Wherein, the capsule material of the soft capsule is made of gelatin, glycerol or suitable medicinal materials.   With the advancement of technology, soft capsule dosage forms have developed rapidly. The contents of soft capsules can be drug solutions and suspensions, etc. Compared with traditional Chinese medicine pills and other dosage forms, they have the advantages of high bioavailability and quick curative effect. The advancement of traditional Chinese medicine extraction and separation technology has also greatly promoted the emergence of traditional Chinese medicine soft capsules. Some traditional Chinese medicines, such as Huoxiangzhengqi pills, have now been changed to Huoxiangzhengqi soft capsules, which are welcomed by patients and doctors. This article will discuss the main production process and equipment of traditional Chinese medicine soft capsules in detail based on our production experience.     1 Production process and production equipment The production process of the soft capsule is shown in Figure 1.   According to the requirements of air cleanliness in the 2010 version of GMP, the traditional Chinese medicine production area of soft capsule dosage form should be in the D-level clean area, including the main production processes such as ingredients, sol, pill pressing, shaping, pill washing, drying, inner packaging (packaging), etc. . Then the outer packaging is located in the general production area.     1.1 Preparation of contents (ingredients) Depending on the nature of the contents, the preparation process and equipment of soft capsules are slightly different. If the content is a solution, that is, the drug can be well dissolved in the solvent (usually oily), it is only necessary to accurately weigh the raw materials and auxiliary materials according to the pre-experimented production prescription, and dissolve them in the liquid dispensing tank. If necessary, it can be heated. to speed up the dissolution rate. If the content is a suspension, the medicinal materials or other ingredients and the liquid excipients in the prescription (such as soybean oil, etc.) need to be uniformly milled with a colloid mill, and the process conditions of the glue mill (such as the speed and time of the glue mill) are determined according to their properties. and times, etc.). A certain amount of suspending agent needs to be added to the suspension during preparation to ensure that the suspension cannot be delaminated within a certain period of time (such as 48-72 h, otherwise the uniformity of the drug will be affected. In addition, during the production process Pay attention to heat preservation to ensure the uniformity of the contents. Traditional Chinese medicine soft capsules are mostly mixed with extracts of traditional Chinese medicines and solvents or other auxiliary materials to make solutions or suspension contents. Some soft capsule technology researches in recent years mainly focus on the contents and solvent (or dispersant, etc.) on the formulation study. The equipment for preparing the contents is mainly a liquid dispensing tank. The two-blade stirring paddle of the dosing tank (Figure 2) is driven by a series of cycloidal pinwheel reducers, and the tank body is polished. A colloid mill is required for suspension preparation (Figure 3). 1.2 Preparation of glue solution (sol) The preparation of glue, commonly known as glue, is a key step to ensure the quality of soft capsules. The glue is generally composed of gelatin, glycerol and purified water. Among them, gelatin is the main component, which directly affects the quality of the glue. The 2010 edition of the Chinese Pharmacopoeia stipulates that gelatin is a product obtained by moderate hydrolysis (acid method, alkali method, acid-base mixing method or enzymatic method) of collagen in animal skin, bone, tendon and ligament, or it is different from the above. A mixture of gelatin products. The quality of gelatin mainly depends on the control of jelly concentration, pH, light transmittance, electrical conductivity, microbial limit and other indicators. 2 The main appearance characteristics of soft capsules are strong plasticity and high elasticity, and depend on the composition of the capsule material, that is, glue, The ratio of plasticizer and water. The glue used for soft capsules is basically gelatin, the plasticizer is glycerol, and the water is preferably deionized water or pure water. The hardness of soft capsules is directly related to the weight ratio between dry gelatin and plasticizer. If the ratio of glycerol:gelatin is 25:100, the obtained dried product (14% water content) is very hard, even harder and thicker than hard capsules; if glycerol:gelatin=60:100, the obtained dried product The resulting product (14% water content) is very soft, yet tangible, soft and elastic, and soft capsules can even be torn open with the fingers. The pellet quality of soft capsules is also closely related to the weight ratio of dry gelatin to purified water. If the moisture is too low, the glue will be too viscous, the tape will be difficult to spread and form, and the pelletizing speed will be slow and abnormal. The product has poor appearance and leaks, and produces many non-adhesive pills and special-shaped pills. The general feeding ratio is water: gelatin = 1:1, but different processes (temperature time, etc.) and different sol equipment, and even different products (such as transparent and shading products, etc.), must also make corresponding formulations and processes. Synchronization Adjustment. After studying the glue formula 3, it is concluded that the ratio of gelatin and water should be 1:1, which can be adjusted slightly. At the same time, titanium dioxide can be added as sunscreen and other auxiliary materials according to requirements. The sol equipment (Figure 4) is mainly composed of a glue tank and the like. In addition to the glue tank, water bath heating is required to provide a heat source of 90~100 ℃ to ensure the viscosity of the glue. Therefore, it is necessary to equip the coil type water heater at the same time. In the glue mixing process, in order to condense the glue liquid bubbles and water vapor in the glue tank when vacuuming, a coil condenser should be equipped at the same time, which has a certain protective effect on the vacuum pump. The working principle of pill pressing: The rubber prepared by the rubber wheels on both sides of the main machine and the gelatin box enter into the gap of the roller mold relatively, and the liquid medicine is injected into the wedge-shaped spray body through the conduit through the feeding pump, and the liquid medicine and rubber are separated by the pressure of the feeding material. Press into the grooves of the two rolling molds. Due to the continuous rotation of the rolling molds, the two rubber sheets in the grooves are formed into two hemispheres, and the liquid medicine is encapsulated in the plastic film, and the remaining rubber sheets are cut and separated. The working principle of the rolling mode soft capsule machine and the soft capsule mold are shown in Figure 7 and Figure 8, respectively.   Before pressing, it is necessary to clean and check the relevant parts of the equipment to ensure the smooth flow of the liquid and the integrity of the sealing gasket. When pressing, attention should be paid to adjusting the injection time to prevent the problem of reducing the content of the capsule due to leakage during injection. During the pressing process, attention should also be paid to the control of the rubber temperature. If the temperature is too high, leakage will occur, and if the temperature is too low, the adhesive effect of the rubber will be poor. Generally, the temperature of the control spray body is 45~50 ℃, and the temperature of the plastic box is 55~60 ℃. If the thicknesses of the two rubber sheets are inconsistent, deformed pellets will appear during the pressing process. Therefore, the thickness of the rubber skin should be controlled, generally 0.7~0.8 mm. The uneven content of the content is also a problem that is easy to occur during the pressing process. There are two common reasons: one is that there are air bubbles in the capsule, which is due to the blockage of the spray body, It is caused by inaccurate injection time, loose rubber joints or poor sealing of rubber pads in the material pump; the second is the production of too large or too small rubber particles, which are mostly caused by the blockage of the spray body. A considerable amount of mesh glue will be produced during the pressing process (Fig. 9). The recycling of mesh glue itself is an effective economic method for enterprises. The mesh glue recycling equipment is mesh glue crusher (Figure 10). 1.4 Washing pills The production of soft capsules requires the use of paraffin oil, which can negatively affect the quality of the capsules and therefore requires cleaning of the formed capsules. The traditional process, which is commonly used at present, is to clean the capsule with alcohol and ether organic solvent, and wash off the paraffin oil sticking to the surface of the capsule. However, the solvent soaked and cleaned capsules will have residual solvent, which will pollute the capsules. The rubber skin itself has natural tension. After soaking and cleaning in the solvent, the rubber skin will lose this tension, and the rubber skin will become dry and brittle, which will greatly shorten the shelf life of the capsule product. After solvent cleaning, adhesion between capsules will also occur. At the same time, explosion-proof requirements are also put forward for the cleaning operation room of organic solvents, and labor protection needs to be paid attention to in production.     1.5 Drying Drying is an important link that affects the quality of soft capsules. At present, the drying of soft capsules on the market is mostly in two forms, one is the baking tray type, and the other is the rotating cage type. The advantage of the tray dryer (Figure 11) is that it occupies a small area, but the disadvantage is that the drying time is long, and it needs to manually turn the tray many times to ensure the drying effect. In the traditional drying method, the shaped soft capsules are placed on a pallet truck and placed in a pill drying room to dry to the finished product. The pill drying room adopts horizontal laminar air supply, the temperature is controlled at 30~35 ℃, and the humidity is controlled below 25%. Each tray is placed with no more than two layers of soft capsules, and the pills are turned inside 4~5 times in the first 2 hours to ensure the soft capsule. The pill shape is good, the appearance is good, and the drying time can be completely dried within 12~16h. Figure 11 Drying tray dryer For rotary cage drying, attention should be paid to the control of indoor humidity and time. In the drying process, the main influencing factor is the indoor humidity. If the indoor humidity reaches 60%, it is very difficult to dry the soft capsule. Time is also an important factor. If the time is too short, the shape of the capsule is not good, and it is easy to deform due to extrusion; if the time is too long, the rubber will be too hard. Generally, the suitable drying time is 16-24 h. The drying equipment is shown in Figure 12. Compared with other dosage forms, soft capsules have the characteristics of high bioavailability, good sealing, accurate content and beautiful appearance, and are a promising dosage form. With the development of soft capsule dosage forms, more soft capsule dosage forms are bound to appear.  
Latest company new about Get Affordable And Versatile SoftGel Capsule Encapsulation Machines From Wuxi JANGLI
2023/01/10

Get Affordable And Versatile SoftGel Capsule Encapsulation Machines From Wuxi JANGLI

Discover Wuxi Jangli Machinery Co. Ltd The Wuxi Jangli Machinery Company manufactures and delivers softgel encapsulation machines, and their complementary equipment. They are a large scale manufacturer with a 6,000m2 production workshop. Their workforce is made up of more than 300 technicians, engineers, and other members of staff. In addition to that, they have more than 20 sets of CNC die roller processing centers as well as other precision instruments. Wuxi Jangli Machinery Co. Ltd is one of the biggest softgel encapsulation machine manufacturers. Therefore, their production capacity is substantial. They sell more than 100 softgel encapsulation machines all over the world every year. This innovative company has also sells more than 1,000 softgel die roller sets for all types of brands and models annually. Moreover, they deliver more than 300 tumble dryer baskets for regular, and intelligent tumble dryers every year. Furthermore, Wuxi Jangli Machinery Co. Ltd has more than 50 lines of softgel machine supporting gear. Some examples of these include gelatin service tanks, gelatin melters, and medicine tanks. Due to the high quality of Wuxi Jangli Machinery Company softgel machines, numerous companies, and clients are inspired to inspect the factory and cooperate with this company! What Is A Softgel Encapsulation Machine? A softgel encapsulation machine is a contraption that you can use to manufacture soft gelatin capsules. This machine fills up and seals soft gelatin capsules. The Wuxi Jangli Machinery Company softgel encapsulation machines are cGMP compliant. They can also be fully automated. Each soft gelatin capsule machine is easy to operate. Your technicians can easily change their softgel encapsulation machines tooling. They can also assemble or disassemble the machine, and also integrate it with other softgel support equipment. All softgel encapsulation machines are available in standard or custom designs to meet a variety of soft gelatin capsule filling needs. Buy Wuxi Jangli Machinery Co. Ltd softgel encapsulation machines to boost your enterprise in the softgel market! What Are Softgel Capsules? Softgel capsules are translucent casings that contain liquid or semi-liquid solutions. The capsules are hermetically sealed in gelatin shells. Millions of people around the world enjoy using softgel capsules for a variety of reasons. These capsules can be customized into specific, preferred shapes and sizes. In addition to that, they facilitate bio-availability. Softgel capsules can be filled with a variety of semi-liquids, liquids, and suspensions. These casings are fitted with airtight seals that are difficult to tamper with. As such, they are safer to use. Most importantly, softgel capsules can be swallowed easily without any water! How Many Types Of Softgel Encapsulation Machines Are Available? The Wuxi Jangli Machinery Co. Ltd manufactures a wide variety of softgel encapsulation machines. Below are some softgel encapsulation machines offered by this company: Softgel Encapsulation Machine Models JL-15II The JL-15II softgel machine model was developed for Medium Scale Capacity. It has compact dimensions and covers a small floor space. This softgel filling machine can also be implemented for Research and Development (R&D) because it consumes low levels of energy. This JL-15II sits above the JL-100II and below the JL-250II models. The Wuxi Jangli Company innovated this model for middle capacity markets. While doing so, they gave it the following characteristics: Medicine Pump: The JL-15II softgel machine has 4 plungers on each side bringing the total to 8 plungers. Each of the plungers is made using stainless steel with HCP. As a result, each unit is durable, and resistant to abrasion. In addition to that, each plunger is designed with high-precision. Therefore, each unit's filling error can be less than 1.5ml. Casting Drum: The casting drum in this softgel-making machine is cooled by the independent industrial chiller. Therefore, its temperature is more accurate. In addition to that, it cools faster. Die Roll Mounting: The Wuxi Jangli Company designers made sure that each die roller can be individually installed. This prevents the die rollers from negatively interacting with each other. As a result, the precision is much higher! Micro-Lubricating Pump: This JL-15II softgel machine uses a micro-lubricating dosing pump to deliver lubricant. Its dosage can be controlled precisely to make micro-lubrication possible. Control Panel: Your engineers can control the JL-15II soft gelatin encapsulation machine interactively through a SIEMENS PLC touch screen panel. Why Buy Your Softgel Encapsulation Machine From The Wuxi Jangli Company? Guaranteed Stability Wuxi Jangli Machinery Co. Ltd is a stable company that has been in active operation for more than 20 years. Their workshop has an area of more than 6,000m2. Furthermore, this facility is administered through a humanization management system. Professional Services The company has more than 40 technicians specializing in product design, development and protocol. They always reply to clients as fast as possible, and ensure efficient operations at all times. A Variety Of Services Available In addition to supplying softgel encapsulation machines, the company also provides other related services. Some examples of these include support, troubleshooting, training, testing, and installation of the Benchtop softgel encapsulation machine and many others. Reliable After-Sales Services After purchasing a softgel encapsulation machine for sale, the Wuxi Jangli Company provides fast delivery and furnishes clients with dependable after-sales services. They perform delivery, installation, training and maintenance. In doing so, they guarantee correct machine operation and assure your organizations profitability! Conclusion Wuxi Jangli Machinery Co. Ltd is your one-stop shop for softgel encapsulation machines. With more than two decades of experience, the company can provide your desired softgel encapsulation equipment. The Wuxi Jangli Company softgel encapsulation machine price is affordable. Moreover, their machines are high-quality and capable of medium to high-capacity production. Some outstanding examples of these include the JL-15II, JL-100II and JL-250II models just to mention a few. Do you have a softgel manufacturing startup? Buy your soft gelatin machine from Wuxi Jangli Machinery Co. Ltd today!
Latest company new about Small Scale Manufacturers Will Love This Table Top Sotfgel Machine From Wuxi JANGLI machinery
2022/05/01

Small Scale Manufacturers Will Love This Table Top Sotfgel Machine From Wuxi JANGLI machinery

Company Profile of Wuxi Jangli Machinery Co. Ltd The Wuxi Jangli Machinery Company is always striving to innovate and find out what their clients desire. They create value for their customers by doing so. Moreover, they have thrived in the softgel encapsulation machine industry for 20 years by maintaining this mentality. Over this time, they have established a 6,000m2 facility that is Sigma 6 rated. There are 20 CNC processing stations within this main workshop. The company manufactures precision instruments such as die rollers here. Also, they employ more than 300 engineers, technicians, and other members of staff to keep the facility running. With this enormous technical and human resource, Wuxi Jangli Machinery Co. Ltd sells more than 100 softgel machines every year. They also sell more than 1,000 softgel die roller sets for various softgel machine models all over the globe. Along with this, they also manufacture accessories for these units. Notably, the company also sells more than 300 baskets for standard, and intelligent tumble dryers annually. At the Wuxi Jangli Machinery Company, the goal is to provide their clients with maximum value. Therefore, they also sell more than 50 lines of softgel machine complementary equipment. Some examples of these include gelatin melters, medicine tanks, and gelatin service tanks among others. Their clients can build entire softgel encapsulation production lines in their facilities using these accessories. Wuxi Jangli Machinery Co. Ltd is considered one of the top softgel encapsulation machine manufacturers in the world due to their Large Scale Capacity production levels. Their positive reputation inspires clients from countries all over the globe to inspect their facility, and sign cooperative deals. Types of Machines Available For You at the Wuxi Jangli Machinery Company There is a variety of softgel encapsulation machines available for purchase from this manufacturer. One of the most notable ones is the Table Top sotfgel machine. It is compact, easy to use and is fit for Small Scale Capacity production. As such, this machine is perfect for implementation in Research and Development (R&D) and laboratory testing. Here is more about the Table Top sotfgel machine. Table Top Softgel Machine Also known as the JL-65II, it is developed especially for R&D, and the development of new products in the laboratory. It is the smallest unit in their lineup that has the basic components required for softgel encapsulation. As such, it can perform all types of encapsulation including making oil or suspension softgel capsules. Here are the characteristics of this JL-65II Table Top soft gelatin encapsulation machine: Stainless Steel Material Hopper: This component contains the material that is to be encapsulated. With a volume of 5 liters, it can provide the machine with fluid for two hours. The single-layer hopper is easy to extract for cleaning, and maintenance. In addition to that, the client can request a custom-made hopper containing additional features such as a mixer or automatic heating.   Material Injection Pump: This section of the machine is made of stainless steel. Moreover, the injection plungers are also made of this material. Stainless steel is light, rust-resistant and immensely durable.   Die Rollers: These components serve as the main encapsulation section of this Table Top sotfgel machine. The die roller size is 64mm x 65mm. Therefore, it can manufacture softgel capsules of various sizes. Best of all, it is easy to adjust the tooling system in this machine. This makes it suitable for Research and Development (R&D), and small batch production. Cooling Drums: This softgel filling machine has a pair of cooling drums. Together, they create the gelatin ribbon. Some cool water from the chiller helps to set a cooler temperature. As a result, the gelatin is formed into a ribbon on the cooling drum. Spreader Box: Sitting above the cooling drum is the spreader box. In addition to spreading the gelatin, it also controls the ribbon's thickness. It is equipped with a heating function, and temperature control as well. Its design makes the spreader box easy to operate and clean. Control Panel: The machine has a SIEMENS PLC touch screen control panel. It presents a user-friendly interface through which technicians can interact, set, and monitor the machine.   Tumble Dryer: This section of the softgel encapsulation machine is used to dry out the softgel capsules. The JL-65II tumble dryer has a capacity of 15kg of softgel capsules. They are usually ready to pack after 4 hours of running this machine. Notably, the tumble dryer can be used for the final drying or shaping and drying purposes.   Thanks to its features, the JL-65II Table Top machine is an ideal piece of equipment for your R&D department, laboratory or educational institution. Why Buy Your Softgel Machine From Wuxi Jangli Machinery Co. Ltd? There are numerous reasons why you should purchase a soft gelatin machine from the Wuxi Jangli Machinery Company. Let's take a look at some of them. It is a Stable Company Wuxi Jangli Machinery Co. Ltd has been in operation for more than two decades. They have sold thousands of units and garnered substantial revenue from their sales. As a result, they built a 6,000m2 facility in which they manufacture high quality softgel encapsulation machines. Professional Services They provide highly professional services to their clients. In addition to delivery, they also perform installation, and maintenance on the machine. This creates convenience for the client. After-Sale Services The Wuxi Jangli Machinery Company provides industry-leading softgel encapsulation machines. In addition to that, they also provide technical support. Moreover, they conduct technician training, troubleshooting, and testing. These services are provided for the machines as well as support equipment. Conclusion The Table Top softgel-making machine is an excellent addition to your R&D department, startup or technical college. Manufactured by Wuxi Jangli Machinery Co. Ltd, it is a compact, easy to use machine. It is also highly versatile so it can be used to make various types of softgel capsules. Are you looking to teach about soft gelatin capsules, or running a startup? Buy the JL-65II at a favorable softgel encapsulation machine price from the Wuxi Jangli Machinery Company today!
Latest company new about 5 Things That Could Go Wrong During Softgel Encapsulation
2022/03/20

5 Things That Could Go Wrong During Softgel Encapsulation

Here are 5 things that could go wrong during soft gel encapsulation: Leaking Capsules Leaking capsules are among the most frequent issues that arise during the encapsulation of softgels. This may happen for many reasons, including poor filling, insufficient sealing, or flawed capsules. When capsules leak, they endanger users' safety, in addition to lowering the product's quality and effectiveness. Investing in high-quality soft gel encapsulation equipment with precise filling and sealing is crucial to preventing capsule leaks. Uneven Fill Weight Uneven fill weight during soft gel encapsulation is another potential problem. This happens when each capsule contains a different amount of fill material, leading to irregular dosages. Inaccurate machine calibration, differences in the fill material's viscosity, and diversity in capsule size are just a few of the causes of uneven fill weight. Purchasing a soft gel encapsulation machine that can precisely manage the filling process is essential to ensuring uniform fill weight. Sticky Capsules Another typical problem that occurs while encapsulating soft gels is sticky capsules. This happens when the gelatin capsules soften excessively and stay together, making it challenging to separate them. High humidity levels, extreme heat, or the use of incompatible excipients are only a few causes of this. With an efficient and effective soft gel encapsulation machine, you do not have to worry about this. Your machine goes a long way in helping you solve this problem. Capsule Brittleness Another problem that can arise during the encapsulation of softgels is capsule brittleness. This happens when the gelatin capsules get overly dry and are more prone to breaking or cracking. This may result from several things, such as low humidity levels, insufficient drying times, or the use of subpar capsules. An effective soft gel encapsulation machine with controllable drying conditions is highly important to avoid capsule brittleness. Formulation Incompatibility Another problem that might occur during the soft gel encapsulation process is formulation incompatibility. The product degrades or has poor stability when the fill substance and the gelatin capsules are incompatible. This may be caused by many things, such as utilizing the incorrect excipients or improper active pharmaceutical components. Often this problem is caused by a faulty machine and sometimes a human error. To control this problem to a large extent, you must purchase a soft gel encapsulation machine that works properly and also invest in its maintenance. Why Choose Jangli Machinery For Your Softgel Encapsulation Machine? We at Jangli Machinery are aware that investing in a soft gel encapsulation machine is a major decision. It's a choice that will have a long-term effect on the caliber and effectiveness of your production process. For this reason, we provide the greatest soft gel encapsulation equipment available, backed by first-class support and customer service. Here are some of the reasons Wuxi Jangli Machinery is the ideal supplier of high-quality soft gel encapsulation equipment: Product Quality And Overall Reliability We ensure you receive a dependable and long-lasting machine that will satisfy your needs by designing and manufacturing our soft gel encapsulation equipment to the highest quality standards. In order to ensure that our high standards are met, we only use the best materials and components in our machines. Additionally, each machine goes through rigorous testing and quality control procedures. Mastery And Assistance We have a group of specialists at Wuxi Jangli Machinery that are enthusiastic about soft gel encapsulation technology. Throughout the entire process, we are always accessible to answer your questions, offer advice, and offer support. Our team has extensive industry knowledge and can assist you in selecting the ideal machine for your unique requirements and price range. Customization Because we recognize that each manufacturing procedure is distinct, so we provide customization choices to satisfy your needs. We can modify our machines to meet your demands, whether you require a specific capsule size, form, or unique features to enhance your manufacturing process. Affordable Prices We at Jangli provide the most affordable soft gel encapsulation equipment without sacrificing quality. Regardless of financial constraints, everyone should be able to purchase a high-quality machine. After-Sale Support When you buy a machine from us, we remain committed to you. We provide continuous support, upkeep, and repair services to keep your machine in top condition. We recognize how crucial it is to reduce downtime, and our staff is committed to keeping your production process operational. Conclusion Quickly put, the success of your production process depends on choosing the correct soft gel encapsulation equipment. To assist you in achieving your production objectives, Jangli Machinery provides quality, dependability, competence, customization, competitive price, and superior after-sales support. Contact us now to learn more about our soft gel encapsulation machine.  
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